July 21, 2019


Stem Cell Therapy for Thalassemias-Hope Medical Group

ThalassemiasThalassemias are a type of inherited blood disorders where parents pass the genes for the disorder on to their children.

Thalassemias cause the body to make fewer healthy red blood cells and less hemoglobin (HEE-muh-glow-bin) than normal. Hemoglobin is an iron-rich protein in red blood cells. It carries oxygen to all parts of the body. Hemoglobin also carries carbon dioxide (a waste gas) from the body to the lungs, where it's exhaled.

Children’s who have thalassemias can have mild or severe anemia (uh-NEE-me-uh). This condition is caused by a lower than normal number of red blood cells or not enough hemoglobin in the red blood cells.

Normal hemoglobin, also called hemoglobin A, has four protein chains—two alpha globin and two beta globin. The two major types of thalassemia, alpha and beta, are named after defects in these protein chains.

Four genes (two from each parent) are needed to make enough alpha globin protein chains. Alpha thalassemia trait occurs if one or two of the four genes are missing. If more than two genes are missing, moderate to severe anemia occurs.

Two genes (one from each parent) are needed to make enough beta globin protein chains. Beta thalassemia occurs if one or both genes are altered.

The severity of beta thalassemia depends on how much one or both genes are affected. If both genes are affected, the result is moderate to severe anemia. The severe form of beta thalassemia is known as thalassemia major or Cooley's anemia.

If your child has thalassemia, blood tests may reveal:

. A low level of red blood cells
. Smaller than expected red blood cells
. Pale red blood cells
. Red blood cells that are varied in size and shape
. Red blood cells with uneven hemoglobin distribution,
. which gives the cells a bull's-eye appearance under the microscope

Blood tests may also be used to:

. Measure the amount of iron in your child's blood
. Evaluate his or her hemoglobin
. Perform DNA analysis to diagnose thalassemia or to determine if a person is carrying mutated hemoglobin genes

Treatments for moderate to severe thalassemia may include:

Frequent blood transfusions. More severe forms of thalassemia often require frequent blood transfusions, possibly every few weeks. Over time, blood transfusions cause a buildup of iron in your blood, which can damage your heart, liver and other organs. To help your body get rid of the extra iron, you may need to take medications that rid your body of extra iron.

Stem cell transplant, a stem cell transplant may be used to treat severe thalassemia.


Stem Cells Transplant Cured Thalassemia


Thalassemia is an inherited blood disorder in which the body makes too much hemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells and anemia. Severe thalassemia can cause early death due to heart failure.

Stem Cells, present in the bone marrow, give rise to red blood cells that produce Hemoglobin. In Thalassemia, it's the defect in the stem cells that leads to deformed red blood cells that produce the abnormal hemoglobin and transfusion dependent anemia. Stem Cell transplantation provides a thalassemia patient with healthy stem cells that will produce normal blood cells.

For more information on stem cell treatment for thalassemia, please complete a medical form here or visit http://hopestemcell.com/ 

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