July 21, 2019


Immunotherapy for Vaginal Cancer-Hope Medical Group

Vaginal Cancer is a rare cancer that occurs in your vagina — the muscular tube that connects your uterus with your outer genitals. Vaginal cancer most commonly occurs in the cells that line the surface of your vagina, which is sometimes called the birth canal.


While several cancers can spread to your vagina from other places in your body, cancer that begins in your vagina (primary vaginal cancer) is rare.


Women with early-stage vaginal cancer have the best chance for a cure. Vaginal cancer that spreads beyond the vagina is much more difficult to treat.



Early vaginal cancer may not cause any signs and symptoms. As it progresses, vaginal cancer may cause signs and symptoms such as:


Unusual vaginal bleeding, for example, after intercourse or after menopause


Watery vaginal discharge

A lump or mass in your vagina

Painful urination


Pelvic pain


It's not clear what causes vaginal cancer. In general, cancer begins when healthy cells acquire a genetic mutation that turns normal cells into abnormal cells. Healthy cells grow and multiply at a set rate, eventually dying at a set time. Cancer cells grow and multiply out of control, and they don't die. The accumulating abnormal cells form a mass (tumor). Cancer cells invade nearby tissues and can break off from an initial tumor to spread elsewhere in the body (metastasize).

Types of vaginal cancer
Vaginal cancer is divided into different types based on the type of cell where the cancer began. Vaginal cancer types include:


Vaginal squamous cell carcinoma, which begins in the squamous cells — thin, flat cells that line the surface of the vagina — and is the most common type




Vaginal adenocarcinoma, which begins in the glandular cells on the surface of your vagina




Vaginal melanoma, which develops in the pigment-producing cells (melanocytes) of your vagina




Vaginal sarcoma, which develops in the connective tissue cells or smooth muscles cells in the walls of your vagina

Risk factors

Factors that may increase your risk of vaginal cancer include:


Increasing age. Your risk of vaginal cancer increases as you age. Most women who are diagnosed with vaginal cancer are older than 50 years of age.




Atypical cells in the vagina called vaginal intraepithelial neoplasia. Women with vaginal intraepithelial neoplasia (VAIN) have an increased risk of vaginal cancer. In women with VAIN, cells in the vagina appear different from normal cells, but not different enough to be considered cancer. A small number of women with VAIN will eventually develop vaginal cancer, though doctors aren't sure what causes some cases to develop into cancer and others to remain benign. VAIN is caused by the sexually transmitted human papillomavirus (HPV), which can cause cervical, vaginal and vulvar cancers, among others. Vaccines that prevent some types of HPV infection are available.




Exposure to miscarriage prevention drug. Women whose mothers took a drug called diethylstilbestrol (DES) while pregnant in the 1950s have an increased risk of a certain type of vaginal cancer called clear cell adenocarcinoma.


Other risk factors that have been linked to an increased risk of vaginal cancer include:


Multiple sexual partners


Early age at first intercourse


HIV infection


Vaginal cancer may spread (metastasize) to distant areas of your body, such as your lungs, liver and pelvic bones.



Cancer is a class of diseases characterized by out-of-control cell growth. There are over 100 different types of cancer, and each is classified by the type of cell that is initially affected.


Cancer harms the body when damaged cells divide uncontrollably to form lumps or masses of tissue called tumors (except in the case of leukemia where cancer prohibits normal blood function by abnormal cell division in the blood stream). Tumors can grow and interfere with the digestive, nervous, and circulatory systems, and they can release hormones that alter body function. Tumors that stay in one spot and demonstrate limited growth are generally considered to be benign.

More dangerous, or malignant, tumors form when two things occur:

A cancerous cell manages to move throughout the body using the blood or lymph systems, destroying healthy tissue in a process called invasion

That cell manages to divide and grow, making new blood vessels to feed itself in a process called angiogenesis.

When a tumor successfully spreads to other parts of the body and grows, invading and destroying other healthy tissues, it is said to have metastasized. This process itself is called metastasis, and the result is a serious condition that is very difficult to treat.

Cancer is ultimately the result of cells that uncontrollably grow and do not die. Normal cells in the body follow an orderly path of growth, division, and death. Programmed cell death is called apoptosis, and when this process breaks down, cancer begins to form. Unlike regular cells, cancer cells do not experience programmatic death and instead continue to grow and divide. This leads to a mass of abnormal cells that grows out of control.

Cancer symptoms are quite varied and depend on where the cancer is located, where it has spread, and how big the tumor is. Some cancers can be felt or seen through the skin - a lump on the breast or testicle can be an indicator of cancer in those locations. Skin cancer (melanoma) is often noted by a change in a wart or mole on the skin. Some oral cancers present white patches inside the mouth or white spots on the tongue.

Other cancers have symptoms that are less physically apparent. Some brain tumors tend to present symptoms early in the disease as they affect important cognitive functions. Pancreas cancers are usually too small to cause symptoms until they cause pain by pushing against nearby nerves or interfere with liver function to cause a yellowing of the skin and eyes called jaundice. Symptoms also can be created as a tumor grows and pushes against organs and blood vessels. For example, colon cancers lead to symptoms such as constipation, diarrhea, and changes in stool size. Bladder or prostate cancers cause changes in bladder function such as more frequent or infrequent urination.

As cancer cells use the body's energy and interfere with normal hormone function, it is possible to present symptoms such as fever, fatigue, excessive sweating, anemia, and unexplained weight loss. However, these symptoms are common in several other maladies as well. For example, coughing and hoarseness can point to lung or throat cancer as well as several other conditions.

When cancer spreads, or metastasizes, additional symptoms can present themselves in the newly affected area. Swollen or enlarged lymph nodes are common and likely to be present early. If cancer spreads to the brain, patients may experience vertigo, headaches, or seizures. Spreading to the lungs may cause coughing and shortness of breath. In addition, the liver may become enlarged and cause jaundice and bones can become painful, brittle, and break easily. Symptoms of metastasis ultimately depend on the location to which the cancer has spread.

There are five broad groups that are used to classify cancer.

Carcinomas are characterized by cells that cover internal and external parts of the body such as lung, breast, and colon cancer.

Sarcomas are characterized by cells that are located in bone, cartilage, fat, connective tissue, muscle, and other supportive tissues.

Lymphomas are cancers that begin in the lymph nodes and immune system tissues.

Leukemias are cancers that begin in the bone marrow and often accumulate in the bloodstream.

Adenomas are cancers that arise in the thyroid, the pituitary gland, the adrenal gland, and other glandular tissues.

Cancers are often referred to by terms that contain a prefix related to the cell type in which the cancer originated and a suffix such as -sarcoma, -carcinoma, or just -oma. Common prefixes include:

Adeno- = gland

Chondro- = cartilage

Erythro- = red blood cell

Hemangio- = blood vessels

Hepato- = liver

Lipo- = fat

Lympho- = white blood cell

Melano- = pigment cell

Myelo- = bone marrow

Myo- = muscle

Osteo- = bone

Uro- = bladder

Retino- = eye

Neuro- = brain


Early detection of cancer can greatly improve the odds of successful treatment and survival. Physicians use information from symptoms and several other procedures to diagnose cancer. Imaging techniques such as X-rays, CT scans, MRI scans, PET scans, and ultrasound scans are used regularly in order to detect where a tumor is located and what organs may be affected by it. Doctors may also conduct an endoscopy, which is a procedure that uses a thin tube with a camera and light at one end, to look for abnormalities inside the body.


Extracting cancer cells and looking at them under a microscope is the only absolute way to diagnose cancer. This procedure is called a biopsy. Other types of molecular diagnostic tests are frequently employed as well. Physicians will analyze your body's sugars, fats, proteins, and DNA at the molecular level. For example, cancerous prostate cells release a higher level of a chemical called PSA (prostate-specific antigen) into the bloodstream that can be detected by a blood test. Molecular diagnostics, biopsies, and imaging techniques are all used together to diagnose cancer.

DC + CIK cells and how to effectively cure cancer

DC cells (dendritic cells) due to mature out of many dendritic-like pseudopodia-like protrusions or named, is known to provide the most powerful antigen presenting cells involved in antigen recognition, processing and presentation, is the most important aspects of the immune response can stimulate the activation of naive T cells, recognize and kill tumor cells and inhibit tumor angiogenesis, while stimulating immune memory protection.

CIK (cytokine-induced killer cells) in vitro by human peripheral blood mononuclear cells from a variety of cytokine-induced expansion of a group of heterogeneous cells, it has a strong anti-tumor activity and the advantages of non-restrictive to kill tumors without killing any other normal tissue cells, for any one of the cancer patients. The cell recognition of tumor cells are strong, especially in postoperative patients with or after chemotherapy treatment significantly, to eliminate residual small metastatic lesions to prevent spread and recurrence of cancer, improve immunity.

In short, DC cells in the human body's own immune system to enhance and rebuild its immune system, automatic identification, tracking tumor cells, and to transmit this information to patients own immune cells, promoting their activation and proliferate outside the Commonwealth of CIK cells back to lose a lot of full identification, tracking, killing tumor cells, to eliminate residual small metastatic lesions to prevent spread and recurrence of cancer, enhance immunity, the purpose of improving the quality of life of patients, ultimately prolong the life of purpose.

DC-CIK cell immunotherapy to treat cancer has the following advantages:

The exact effect, the effective rate. For some cancer , have efficiencies up to 80%.


No radiotherapy and chemotherapy side effects, the patient is not suffering, well tolerated, to kill tumor specificity.


Can stimulate systemic anti-cancer effects of multiple lesions or metastatic malignant tumors to be effective.


The treatment helps the body to quickly restore from radiotherapy and chemotherapy sent to destroy cancers and the immune system while improving the long-term cancer-fighting ability.


The effect on cancer recurrence offer significant, long-term anti-cancer effects.


Can be used alone can also be used in combination with other treatments. A single effective, repeated use, the better.

 For more information on stem cell treatment for Vaginal Cancer, please complete a medical form here or visit http://www.hopestemcell.com/cancer-immunology

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